The Balloon Effect
Imagine a balloon. When the opening is small or closed, the pressure inside stays low. But blow air into it, and it wants to expand - pushing outward on all sides.
Buildings work exactly the same way. When wind forces its way through an opening in the windward wall, it pressurizes the interior like inflating a balloon.
This internal pressure pushes outward on every surface - walls, roof, windows. It adds to the suction already pulling on the leeward side, making total loads much higher.
That is why a broken window during a hurricane can lead to roof failure - the internal pressure was never part of the original design.